Maintaining cellular homeostasis in the face of environmental stress is paramount to cell survival. In this course we will examine the cellular and molecular responses of eukaryotic cells to stress at the levels of DNA, RNA, and protein, with consideration of organelle-specific responses. Topics will include heat shock, osmotic stress, hypoxia, starvation, and oxidative stress. This course focuses primarily on conserved and mammalian mechanisms activated in response to macromolecular strain, rather than stress responses unique to organisms adapted to environmental extremes. Throughout the course, we will discuss the evolution and conservation of the cellular stress response, connections to disease, as well as the challenges and future directions of the field. This course will consist of lectures, invited seminars from researchers in the field, and discussion of scientific reviews and primary articles. Articles will showcase classic stress response research as well as new findings and methods in the field.

Units: 1

Max Enrollment: 12

Prerequisites: Two 200-level BISC/BIOC courses. At least one of these must be BISC 219/BIOC 219 or BISC 220/BIOC 220.

Instructor: Staff

Distribution Requirements: NPS - Natural and Physical Sciences

Typical Periods Offered: Spring

Semesters Offered this Academic Year: Not Offered

Notes: