Cell biology was born in the microscope, which now allows us to visualize the dynamic processes of life inside cells. This course takes an interdisciplinary approach to examine how scientists address physiologically significant questions using microscopy and imaging approaches. The course’s main goal is to empower students to explore and evaluate the use of microscopy in cell and molecular biology. We study the development and utilization of qualitative and quantitative optical microscopy techniques, focusing on fluorescence microscopy. Theoretical and practical fundamentals are discussed, and student analysis of review and primary literature is integral to this course. Class meetings may include a combination of introductory lectures, literature discussions, student presentations throughout the semester, and hands-on experience in the laboratory where students work with research-grade microscopes. Student-designed investigations will incorporate the expression and assessment of fluorescent protein tags in mammalian cell model systems with an emphasis on experimental design and image analysis. Assignments and activities are designed to help students learn to collaborate successfully to solve problems in an interdisciplinary team.

Units: 1.25

Max Enrollment: 12

Prerequisites: Two 200-level BISC or BIOC courses, one of which is BISC 219/BIOC 219 or BISC 220/BIOC 220, or permission of the instructor. Not open to students who have taken BISC 328.

Distribution Requirements: LAB - Natural and Physical Sciences Laboratory; NPS - Natural and Physical Sciences

Typical Periods Offered: Fall

Semesters Offered this Academic Year: Fall

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